Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1995-06-05
1998-03-31
Seidleck, James J.
Drug, bio-affecting and body treating compositions
Dentifrices
A61K 716
Patent
active
057335290
ABSTRACT:
The present invention relates to various toothpastes containing, stable, dispersions of certain high viscosity silicones in certain surfactants; wherein:
a. the dispersed silicones, which contain triclosan, 2,4,4'-triclosan-2'-hydroxy/epoxy/ether, are insoluble in said surfactant, are oriented by the surfactant such that when dispersed in water they are particularly adept at forming oriented, nonhelical coatings on surfaces of the mouth with enhanced substantivity, and
b. the particle size of the dispersed silicone is from between about 0.1 and about 10 microns, with a particle size distribution such that from between about 80 and 95% of the dispersed silicone is within this particle size range. These stable dispersions are described as ULTRAMULSION dispersions, which, together with their physical properties, when contained in toothpastes, provide the toothpaste with enhanced with enhanced substantivity to mouth surfaces, where the non continuous silicone phase functions as a reservoir for the triclosan contained therein.
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Brown Dale G.
Hill Ira D.
Walters Peter P.
Linek Ernest V.
Seidleck James J.
WhiteHill Oral Technologies, Inc.
Williamson Michael A.
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