Ultra sensitive biosensor for detecting bio-signal...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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07842471

ABSTRACT:
The present invention relates to a novel use of a transfected cell as a biosensor, wherein the transfected cell expresses a receptor specific to a bio-signal transmitter, and a highly sensitive detector and a highly sensitive detecting method of a bio-signal transmitter using the biosensor. The bio-signal transmitter detecting technique according to the present invention has an advantage of being applied to a sniffer-patch method, and is capable of providing millisecond time resolution for detecting nanomolar levels of the bio-signal transmitter to be detected.

REFERENCES:
patent: 6376198 (2002-04-01), Kopin et al.
patent: 10-0560122 (2005-12-01), None
Lee et al., J Physiol 581(3):1057-1081, 2007 (first published on-line Apr. 5, 2007).
Pasti et al., Journal of Neuroscience, 21(2):477-484, 2001.
Stern-Bach et al., Neuron, 21:907-918, 1998.
Allen, T.G.J., Trends Neurosci., vol. 20, No. 5, pp. 192-197 (1997), The ‘sniffer-patch’ technique for detection of neurotransmitter release.

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