Ultra pure hemoglobin solutions and blood-substitutes

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530427, C07K 114, C07K 14805

Patent

active

056189192

ABSTRACT:
A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.

REFERENCES:
patent: 3959128 (1976-05-01), Harris
patent: 3991181 (1976-11-01), Doczi
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4059512 (1977-11-01), Harris
patent: 4061736 (1977-12-01), Morris et al.
patent: 4133874 (1979-01-01), Miller et al.
patent: 4136093 (1979-01-01), Bonhard et al.
patent: 4300717 (1981-11-01), Latham, Jr.
patent: 4314997 (1982-02-01), Shanbrom et al.
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4439357 (1984-03-01), Bonhard et al.
patent: 4473494 (1984-09-01), Tye
patent: 4526715 (1985-07-01), Kothe et al.
patent: 4529719 (1985-07-01), Tye
patent: 4532130 (1985-07-01), Djordjevich et al.
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4826811 (1989-05-01), Sehaal et al.
patent: 5084558 (1992-01-01), Rausch et al.
patent: 5296465 (1994-03-01), Rausch et al.
patent: 5464814 (1995-11-01), Sehgal et al.
Feola et al, "Development of a Bovine Stroma-Free Hemoglobin Solution . . .", Surgery, Nov. 1983, vol. 157, pp. 399-408.
Issekutz, J. Immunol. Methods, 61:275-281 (1983).
Breepoel, P.M. et al., Pfugers Arch., 389:219-225 (1981).
Bunn, H.F., Science, 172:1049-1050 (1971).
Foela et al., Surgery, Gynecology & Obsterics, pp. 211-221 (1988).
Fronticelli et al., J. Biol. Chem., 259:10841-4 (1984).
"International Drug and Device Regulatory Monitor," Appendix D, U.S. Govt. Print. Office: 1988-20-1-874/83629 (1987).
KabiVitrum Brochure (1987).
Shanbrom et al.,"Endotoxins and Their Detections with Limulus Amebocyte Lysate Test," pp. 105-113, Allan R. Liss, Inc. (1982).
Nachum and Neely, "Clinical Diagnostic Usefulness of the Limulus Amoebocyte Lysat Assay", Laboratory Medicine, 13(2):112-117 (1982).
Pearson III and Weary, "The Limulus Amebocyte Lysat Test for Endotoxin", BioScience, 30(7):461-464 (1980).
Sofer, Gail, "Chromatographic Removal of Pyrogens", Bio/Technology, 1035-1038 (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ultra pure hemoglobin solutions and blood-substitutes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ultra pure hemoglobin solutions and blood-substitutes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ultra pure hemoglobin solutions and blood-substitutes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2398502

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.