Ultra pure hemoglobin solutions and blood-substitutes

Details Ultra pure hemoglobin solutions and blood-substitutes Ultra pure hemoglobin solutions and blood-substitutes

1992-01-13

1994-03-22

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530385, A61K 3714, C07K 302, C07K 322, C07K 1522

Patent

active

052964655

ABSTRACT:
A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.

REFERENCES:
patent: 3959128 (1976-05-01), Harris
patent: 4059512 (1977-11-01), Harris
patent: 4314997 (1982-02-01), Shanbrom et al.
patent: 4826811 (1989-05-01), Sehgal et al.
Feola et al., "Development of a Bovine Stromen Free Hemoglobin Solution . . . ", Surgery, Nov. 1983, vol. 157, pp. 399-408.

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