Ultra-high-mass mass spectrometry with charge discrimination usi

Radiant energy – Ionic separation or analysis

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250287, 250397, H01J 4940

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active

059946946

ABSTRACT:
An ultra-high-mass time-of-flight mass spectrometer using a cryogenic particle detector as an ion detector with charge discriminating capabilities. Cryogenic detectors have the potential for significantly improving the performance and sensitivity of time-of-flight mass spectrometers, and compared to ion multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions and can be used as "stop" detectors in time-of-flight applications. In addition, their energy resolving capability can be used to measure the charge state of the ions. Charge discrimination is very valuable in all time-of-flight mass spectrometers. Using a cryogenically-cooled Nb-Al.sub.2 O.sub.3 -Nb superconductor-insulator-superconductor (SIS) tunnel junction (STJ) detector operating at 1.3 K as an ion detector in a time-of-flight mass spectrometer for large biomolecules it was found that the STJ detector has charge discrimination capabilities. Since the cryogenic STJ detector responds to ion energy and does not rely on secondary electron production, as in the conventionally used microchannel plate (MCP) detectors, the cryogenic detector therefore detects large molecular ions with a velocity-independent efficiency approaching 100%.

REFERENCES:
patent: 5640010 (1997-06-01), Twerenbold
D. Twerenbold et al., "Detection of Single Macromolecules Using a Cryogenic Particle Detector Coupled To A Biopolymer Mass Spectrometer," Applied Physics Letters, 68 (1996) 3503.
D. Twerenbold, "Biopolymer Mass Spectrometer With Cryogenic Particle Detectors," Nuclear Instruments and Methods, Physics Research, A 370, (1996) 253-255.
D. Twerenbold, "Cryogenic Particle Detectors," Rep. Progr., Part. Phys. 59 (1996) 349-426.
M. Frank et al., "High-Efficiency Detection of 66 000 Da Protein Molecules Using A Cryogenic Detector In A Matrix Assisted Laser Desorption/Ionization Time-Of Flight Mass Spectrometer," Rapid Communications In Mass Spectrometry, vol. 10, 1946-1950 (1996).
M. Frank et al., "High-Efficiency Detection of 66 000 Da Protein Molecules Using A Cryogenic Detector In A Matrix-Assisted Laser Desorption/Ionization Time-Of Flight Mass Spectrometer," Rapid Communications In Mass Spectrometry, vol. 10, 1946-1950 (1996).
W. Henry Benner et al., "Simultaneous Measurement of Flight Time . . . ," American Society for Mass Spectrometry, 1997 pp. 1094-1102.

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