Ultra high affinity neutralizing antibodies

Details Ultra high affinity neutralizing antibodies Ultra high affinity neutralizing antibodies

2003-09-08

2010-06-22

Mosher, Mary E (Department: 1648)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S141100

Reexamination Certificate

active

07740851

ABSTRACT:
Ultra high affinity antibodies with binding affinities in the range of 1010M−1, and even 1011M−1are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.

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