Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1997-07-25
1999-06-22
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435 4, 435975, 4353201, 424 934, 424 932, 530300, 530387, C12Q 148, C12Q 100, G01N 3353
Patent
active
059142448
ABSTRACT:
Soluble, enzymatically active CMV UL97 and methods of detecting inhibitors and enhancers of its ability to phosphorylate are disclosed.
REFERENCES:
Britt, William J., "Human Cytomegalovirus Virion-Associated Protein with Kinase Activity", Journal of Virology, Jul. 1986, pp. 185-188.
Chee, M.S., et al., Alpha-, Beta- and Gammaherpesviruses Encode a Putative Phosphotransferase, J. gen. Virol., 1989, pp. 1151-1160.
Coulter, L.J., et al., "A mutant of herpes simplex virus type 1 in which the UL13 protein kinase gene is disrupted", Journal of Gen. Virology, 1993, pp. 387-395.
De Wind, Niels, et al., "Herpesviruses Encode an Unusual Protein-Serine/Thereonine Kinase Which is Non-Essential for Growth in Cultured Cells", Journal of Virology, Sep. 1992, pp. 5200-5209.
Edelman, Arthur M., "Protein Serine/Threonine Kinases", Ann. Rev. Biochem., 1987, pp. 567-613.
Hanks, Steven K., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains", Science, vol. 241, pp. 42-52. (Jul. 1988).
Heineman, Thomas C., "The Varicella-Zoster Virus (VZV) Open Reading Frame 47 (ORF47) Protein Kinase is Disp. for Viral Replication and is Not Required for Phosphorylation of ORF63 Protein, the VZV Homolog of Herpes Simplex Virus ICP22", Journal of Virology, Nov. 1995, pp. 7367-7370.
Hubbard, Stevan R., "Crystal structure of the tyrosine kinase domain of the human insulin receptor", Nature, vol. 372, Dec. 22/29, 1994, pp. 746-754.
Knighton, Daniel R., et al., "Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase", Science, Jul. 26, 1991, pp. 407-414.
Mar, Eng-Chun, et al., Human Cytomegalovirus-associated DNA Polymerase and Protein Kinase Activities, Journal of Gen. Virology, 1981, 57, pp. 149-156.
Michelson, Susan, et al., "Catalytic properties of a human cytomegalovirus-induced protein kinase", Eur. J. Biochem, Feb. 1985, 149, pp. 393-399.
Michelson, S., et al., "Properties of a Human Cytomegalovirus-Induced Protein Kinase", Virology, 1984, pp. 259-268.
Overton, Hilary, et al., "Production of Host Shutoff-Defective Mutants of Herpes Simplex Virus Type 1 by Inactivation of the UL13 Gene", Virology, 202, 1994, pp. 97-106.
Pearson, Richard B., et al., "Autoregulation of Enzymes by Pseudosubstrate Prototypes: Myosin Light Chain Kinase", Science, vol. 241, pp. 970-973, (Aug. 1988).
Roby, Clinton, et al., "Characterization of Phosphoproteins and Protein Kinase Activity of Virions, Non-infectious Enveloped Particles, and Dense Bodies of Human Cytomegalovirus", Jour. of Virol, Sep. 1986, pp. 714-727 (1980).
Sullivan et al., "A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalo-virus-infected cells", Nature, Jul. 9, 1992, vol. 358, pp. 162-164.
Sullivan et al., Erratum: "A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells", Nature, Sep. 3, 1992, vol. 359, p. 85.
Sullivan et al., Erratum: A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells, Nature, Dec. 23/30, 1993, vol. 366, pp.756.
Sullivan et al., A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyl alkyl derivatives, Antimicrob. Agents & Chemo. Jan. 1993 vol.37 No.1, pp. 19-25.
Van Zeijl et al., The human cytomegalovirus UL97 protein is phosphorylated and a component of virions, Virology, 1997, vol. 231, pp. 72-80. Month not available.
Rawlinson et al., The murine cytomegalovirus (MCMV) homolog of the HCMV phosophotransferase (UL97(pk)) gene Virology, 1997, vol. 233, pp. 358-363. Month not available.
International Search Report of PCT/US97/13340 dated Oct. 7, 1997 (6 pp.).
He et al; Jour. of Virology; vol. 71(1); pp. 405-411, Jan. 1997.
Coen Donald M.
He Zuwen
Leary Louise N.
President and Fellows of Harvard College
LandOfFree
UL97 fusion proteins and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with UL97 fusion proteins and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and UL97 fusion proteins and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1707788