UDPG as a rescue agent in cancer therapy after the administratio

Details UDPG as a rescue agent in cancer therapy after the administratio UDPG as a rescue agent in cancer therapy after the administratio

1994-01-06

1996-02-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 51, 514274, 514 63, A61K 3170, A61K 31505, A61K 31695

Patent

active

054949009

ABSTRACT:
A method of rescuing healthy cells of a cancer patient being treated with antipyrimidine antitumor compounds, or related compounds. Rescue is accomplished by administering UDPG after administering the antipyrimidine antitumor compound preferably with BAU administration.

REFERENCES:
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Yip et al., Biochemical Pharmacology, vol. 36, No. 5, pp. 633-637, Mar. 1, 1987.
Martin et al, "Use of Oral Uridine as a Substitute for Parenteral Uridine Rescue of 5-Fluorouracil Therapy, With and Without the Uridine Phosphorylase Inhibitor 5-Benzylacyclouridine", Cancer Chemotherapy and Pharmacology, 24, 1989, pp. 9-14.
Darnowski et al, "Tissue-specific Enhancement of Uridine Utilization and 5-Fluorouracil Therapy in Mice by Benzylacyclouridine", Cancer Research, vol. 45, Nov. 1985, pp. 5364-5368.
Groeningen et al, "Clinical and Pharmacokinetic Studies of Prolonged Administration of High-Dose Uridine Intended for Rescue From 5-FU Toxicity", Cancer Treatment Reports, vol. 70, No. 6, Jun. 1986, pp. 745-750.
Groeningen et al, "Reversal of 5-Fluorouracil Induced Myelosuppression by Prolonged Administration of High-Dose Uridine", Reports, Journal of the National Cancer Institute, vol. 81, No. 2, Jan. 18, 1989, p. 157.

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