UDP-glucose pyro phosphorylase enzymes from nonparasitic protozo

Details UDP-glucose pyro phosphorylase enzymes from nonparasitic protozo UDP-glucose pyro phosphorylase enzymes from nonparasitic protozo

1997-03-03

2000-11-07

Marx, Irene

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4352581, 435947, C12N 912

Patent

active

061435392

ABSTRACT:
The present invention relates to nucleotide-sugar-synthesizing enzymes (enzymes with nucleotidyltransferase or pyrophosphorylase activity) from nonparasitic protists, to a process for the preparation thereof and to the use thereof for preparing nucleotide-sugars. The enzymes according to the invention make possible or greatly simplify the enzymatic preparation of various nucleotide-sugars on the industrial scale from low-cost precursors. It is possible with the aid of the discovered enzymes to prepare, for example, GDP-fucose, GDP-mannose, UDP-glucose, UDP-glucosamine, UDP-galactose, UDP-galactosamine, UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in economic quantities.

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