UCN-1028D derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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Details

514481, 514483, 514510, 514513, 514517, 514533, 514541, 514542, 514544, 514546, 514548, 514550, 514551, 514680, 514686, 552295, 558 44, 558 46, 558 47, 558 48, 558 49, 558 50, 558 51, 558 52, 558260, 558266, 558267, 558268, 558269, 558276, 558277, 558392, 558398, 558406, 558408, 558409, 558410, 558427, 560 9, 560 20, 560 22, 560 23, 560 76, 560 28, 560 29, 560 32, 560 33, 560187, 560188, 560189, 568306, 568326, A01N 3500, A01N 4710, A01N 3700, C07C 5010, C07C30300, C07C26100, C07C 49115

Patent

active

051400448

ABSTRACT:
A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.

REFERENCES:
patent: 4719236 (1988-01-01), Bair
patent: 4731468 (1988-03-01), Gessou et al.
patent: 4945108 (1990-07-01), Grabley et al.
The Journal of Antibiotics, vol. XLII, No. 10, 1470-1474, 1475-1481.
Agricultural & Biological Chemistry, 39, (8), 1683-1684 (1975).
J. Jap. Pasture, 28, (4), 426-432 (1983).
Phytochemistry, 27 (6), 1675-1678 (1988).

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