Ubiquitous immunopoietic polypeptide (UBIP) and methods

Details Ubiquitous immunopoietic polypeptide (UBIP) and methods Ubiquitous immunopoietic polypeptide (UBIP) and methods

1975-08-22

1977-01-11

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700, A61K 3700

Patent

active

040026027

ABSTRACT:
There is disclosed a new Ubiquitous Immunopoietic Polypeptide (UBIP) which has been isolated in fluffy white powder form from bovine thymus but which has been found to be present in living cellular tissue of all animals and plants tested including various guinea pig tissues, cells in tissue cultures and tissues from birds, fish, squid, plants, fungi and bacteria, the polypeptide being characterized by its ability to induce in vitro, in nanogram concentrations, the differentiation of both T cell and B cell immunocytes from precursors present in bone marrow or spleen and thus the polypeptide is useful in therapeutic areas involving thymic or immunity deficiencies and the like. The polypeptide also exhibits hypotensive properties. The polypeptide is isolated from living source materials by a combination of sizing techniques and ion-exchange chromatography and may be described by the following amino acid structural sequence:
H.sub.2 n-met-gln-ile-phe-val-lys-thr-leu-thr-gly-lys-thr-ile-thr-leu-glu-val-glu- pro-ser-asp-thr-ile-glu-asn-val-lys-ala-lys-ile-gln-asp-lys-glu-gly-ile-pro -pro-asp-gln-gln-arg-leu-ile-phe-ala-gly-lys-gln-leu-glu-asp-gly-arg-thr-le u-ser-asp-tyr-asn-ile-gln-lys-glu-ser-thr-leu-his-leu-val-leu-arg-leu-arg-c ooh

REFERENCES:
patent: 3951939 (1976-04-01), Fritz et al.

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