Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1993-01-15
1996-02-27
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435223, 435226, C12N 950, C12N 958, C12N 964
Patent
active
054948185
ABSTRACT:
The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.
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Baker Rohan T.
Tobias John W.
Varshavsky Alexander
Farrell Kevin M.
Grimes Eric
Massachusetts Institute of Technology
Wax Robert A.
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