Ubiquitin-lytic peptide fusion gene constructs, protein products

Details Ubiquitin-lytic peptide fusion gene constructs, protein products Ubiquitin-lytic peptide fusion gene constructs, protein products

1995-07-21

1999-09-21

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530858, 514 12, A61K 3800

Patent

active

059555734

ABSTRACT:
Stabilized ubiquitin-lytic peptide fusion polypeptides and a method of making the same by sub-cloning nucleic acid sequences coding for lytic peptides into a plasmid vector comprising a promoter and ubiquitin polypeptide coding sequence, wherein the ubiquitin polypeptide sequence is linked to the 5' end of the lytic peptide nucleic acid sequence and is translated as a fusion polypeptide.

REFERENCES:
patent: 5294605 (1994-03-01), Houghten et al.
patent: 5357044 (1994-10-01), Lai et al.
N.E. Hoffman et al., "Isolation and characterization of . . . ubi3", Plant Molecular Biology 17, pp. 1189-1201, 1991.
J.E. Garbarino et al., "Isolation of a ubiquitin-ribosomal . . . plants", Plant Molecular Biology 24, pp. 119-127, 1994.
J.E. Garbarino et al., "Isolation of a Polyubiquitin . . . Plants", Plant Physiol. 109, pp. 1-8, 1995.

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