Ubiquitin-like conjugating protein

Details Ubiquitin-like conjugating protein Ubiquitin-like conjugating protein

1997-12-12

1999-10-19

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435183, 4352523, 43525411, 435325, 4353201, 536 232, 536 234, 536 243, C12Q 168, C12N 900, C12N 500, C07H 2104

Patent

active

059687479

ABSTRACT:
The invention provides a human ubiquitin-like conjugating protein (UBCLE) and polynucleotides which identify and encode UBCLE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of UBCLE.

REFERENCES:
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Ciechanover, Aaron, "The Ubiquitin-Proteasome Proteolytic Pathway" Cell (1994) 79:13-21.
Jentsch, Stefan, "The Ubiquitin-Conjugating System," Annu.Rev.Genet. (1992) 26:179-207.
Jensen, J.P. et al. "Identification of a Family of Closely Related Human Ubiquitin Conjugating Enzymes" (1995) 270:30408-30414.
Monia, B.P. et al., "Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins." J.Biol.Chem. (1989) 264:4093-4103.
van Nocker, S. et al., "The Arabidopsis Thaliana UBC7/13/14 Genes Encode a Family of Multiubiquitin Chain-forming E2 Enzymes." J.Biol.Chem. (1996) 271:12150-12158.
Llovera, M. et al., "Muscle Wasting Associated with Cancer Cachexia is Linked to an Important Activation of the ATP-Dependent Ubiquitin-Mediated Proteolysis" Int.J.Cancer (1995) 61:138-141.
Gregori, L. et al., "Ubiquitin-Mediated Degradative Pathway Degrades the Extracellular but not the Intracellular Form of Amyloid .beta.-Protein Precursor" Biochem.Biophys.Res.Commun. (1994) 203:1731-1738.
Grant, E.P. et al., "Rate of Antigen Degradation by the Ubiquitin-Proteasome Pathway Influences MHC Class I Presentation" J.Immunol. (1995) 155:3750-3758.
Jensen, J.P. et al., GI 145691, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Nov. 13, 1995.
Jensen, J.P. et al., GI 145690, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, Mar. 7, 1996.

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