Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1997-05-21
1998-10-06
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
4352523, 4353201, 536 232, 536 235, C12N 900, C12N 120, C12N 1500, C07H 2104
Patent
active
058174940
ABSTRACT:
The present invention provides a human ubiquitin conjugation system protein (UCSP) and polynucleotides which encode UCSP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of UCSP.
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Monia, B.P. et al., "Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins", J. Biol. Chem. 264: 4093-4099 (1989).
Sommer, T. et al., "A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum", Nature, 365: 176-179 (1993) (GI 397581).
Wilson, R. et al., (Direct Submission), GenBank Sequence Database (Accession Z71262), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1279275) (GI 1279278).
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Yoshioka, S., (Direct Submission), GenBank Sequence Database (Accession D89248), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1749703) (GI 1749704).
Bandman Olga
Corley Neil C.
Lal Preeti
Shah Purvi
Billings Lucy J.
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Slobodyansky Elizabeth
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