Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using bacteria
Reexamination Certificate
2005-03-15
2005-03-15
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using bacteria
C435S171000, C435S071100, C514S008100, C514S168000, C424S234100
Reexamination Certificate
active
06867024
ABSTRACT:
A composition is provided that includes an ubiquinone, such as CoQ10, bound by a glycoprotein matrix. A method is also provided for the manufacture of a composition of the invention. The glycoprotein matrix can be formed by permitting the growth of glycoprotein producing bacteria in the presence of the ubiquinone. The composition of the invention provides a method for increasing the stability and bioactivity of the ubiquinone. A method is also provided for administering an ubiquinone to a host by utilizing a composition of the invention.
REFERENCES:
patent: 3196018 (1965-07-01), Galler
patent: 4654373 (1987-03-01), Bertelli
patent: 5008118 (1991-04-01), Iwanami et al.
patent: 5639787 (1997-06-01), Riordan et al.
patent: 5747071 (1998-05-01), Segall et al.
patent: 5891469 (1999-04-01), Amselem
patent: 5912272 (1999-06-01), Hoppe et al.
patent: 5950634 (1999-09-01), Ochi et al.
patent: 5989583 (1999-11-01), Amselem
patent: 6045826 (2000-04-01), Borowy-Borowski et al.
patent: 6054261 (2000-04-01), Masterson
patent: WO 9617626 (1996-06-01), None
Navarro, et al., “Protective Role in Ubiquinone in Vitamin E and Selenium-Deficient Plasma Membranes”,BioFactors 9, pp. 163-170 (1999).
Hoppe, et al., “Coenzyme Q10, a Cutaneous Antioxidant and Energizer”,BioFactors 9, pp. 371-378 (1999).
Hodges, et al., “CoQ10: Could It Have a Role in Cancer Management?”,BioFactors 9, pp. 365-370 (1999).
Langsjoen, et al., “Overview of the Use of CoQ10in Cardiovascular Disease”,BioFactors 9, pp. 273-284 (1999).
Baroni, et al., “Monounsaturated Diet Lowers LDL Oxidisability in Type Iib and Type IV Dyslipidemia Without Affecting Coenzymes Q10and Vitamin E Contents”,BioFactors 9, pp. 325-330 (1999).
Pedersen, et al., “High Serum Coenzyme Q10, Positively Correlated with Age, Selenium and Cholesterol, in Inuit of Greenland. A Pilot Study.”,BioFactors 9, pp. 319-323 (1999).
Niibori, et al., “Bioenergetic Effect of Liposomal Coenzyme Q10on Myocardial Ischemia Reperfusion Injury”,BioFactors 9, pp. 307-313 (1999).
Tomasetti, et al., Distribution of Antioxidants Among Blood Components and Lipoproteins: Significance of Lipids/CoQ10Ratio as a Possible Marker of Increased Risk for AtherosclerosBioFactors 9, pp. 231-240 (1999).
Chida, et al., “In vitro Testing of Antioxidants and Biochemical End-Points in Bovine Retina Tissue”,Ophthalmic Research, 31:407-415 (1999).
Bianchi, et al., “Oxidative Stress and Anti-Oxidant Metabolites in Patients with Hyperthyroidism: Effect of Treatment”,Horm. Metab. Res., 31:620-624 (1999).
Al-Bekairi, et al., “Coenzyme Q10Ameliorates the Hepatic Toxicity Induced by Carbon Tetrachloride in Mice”,Research Communications in Pharmacology and Toxicology, vol. 4, Nos. 3 & 4, pp. 163-171 (1999).
Yokoyama, et al., “Coenzyme Q10Protects Coronary Endothelial Function from Ischemia Reperfusion Injury Via an Antioxidant Effect”,Surgery, vol. 120, No. 2, pp. 189-196 (1996).
Morita, et al., “Studies of Hypoxemic/Reoxygenation Injury: Without Aortic Clamping VII. Counteraction of Oxidant Damage by Exogenous Antioxidants: Coenzyme Q10”,The Journal of Thoracic and Cardiovascular Surgery, , vol. 110, No. 4, Part 2, pp. 1221-1227 (1995).
Lass, et al., “Effects of Coenzyme Q10and α-Tocopherol Administration on Their Tissue Levels in the Mouse: Elevation of Mitochondrial α-Tocopherol by Coenzyme Q10”,Free Radical Biology&Medicine, vol. 26, Nos. 11/12, pp. 1375-1382 (1999).
Nielsen, et al., “No Effect of Antioxidant Supplementation in Triathletes on Maximal Oxygen Uptake,31P-NMRS Detected Muscle Energy Metabolism and Muscle Fatigue”,Int. J. Sports Med., 20: 154-158 (1999).
Alleva, et al., Oxidation of LDL and Their Subfractions: Kinetic Aspects and CoQ10ContenMolec. Aspects Med., vol. 18 (Supplement), pp. S105-s112 (1997).
Tomasetti, et al., “Coenzyme Q10Enrichment Decreases Oxidative DNA Damage in Human Lymphocytes”,Free Radical Biology&Medicine, vol. 27, Nos. 9/10, pp. 1027-1032 (1999).
Aejmelaeus, et al., “Ubiquinol-10 and Total Peroxyl Radical Trapping Capacity of LDL Lipoproteins During Aging: the Effects of Q-10 Supplementation”,Molec. Aspects Med., vol. 18 (Supplement), pp. s113-s120 (1997).
Kagan, et al., “Coenzyme Q10Can in Some Circumstances Block Apoptosis, and This effect Mediated through Mitochondria”,Annals New York Academy of Sciences, pp. 31-47.
Hoffman & Baron LLP
Pharmachem Laboratories, Inc.
Witz Jean C.
LandOfFree
Ubiquinone composition and methods related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ubiquinone composition and methods related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ubiquinone composition and methods related thereto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3443290