UBC7-like ubiquitin-conjugating enzyme

Details UBC7-like ubiquitin-conjugating enzyme UBC7-like ubiquitin-conjugating enzyme

1999-01-26

1999-09-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435193, 536 232, 536 235, 536 243, 536 2431, C12Q 168, C12N 910, C07H 2104

Patent

active

059521813

ABSTRACT:
The invention provides a human ubiquitin-conjugating enzyme (HUCE-1) and polynucleotides which identify and encode HUCE-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HUCE-1.

REFERENCES:
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Monia, B.P. et al., "Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins." J. Biol. Chem. (1989) 264:4093-4103.
van Nocker, S. et al., "The Arabidopsis Thaliana UBC7/13/14 Genes Encode a Family of Multiubiquitin Chain-Forming E2 Enzymes."J. Biol. Chem. (1996) 271:12150-12158. (GI 992703; GI 992704).
Llovera, M. et al., "Muscle Wasting Associated With Cancer Cachexia Is Linked To An Important Activation Of The ATP-Dependent Ubiquitin-Mediated Proteolysis." Int. J. Cancer (1995) 61:138-141.
Gregori, L. et al., "Ubiquitin-Mediated Degradative Pathway Degrades The Extracellular But Not The Intracellular Form Of Amyloid .beta.-Protein Precursor." Biochem. Biophys. Res. Comm. (1994) 203:1731-1738.
Grant, E.P. et al., "Rate of Antigen Degradation by the Ubiquitin-Proteasome Pathway Influences MHC Class I Presentation." J. Immuno. (1995) 155:3750-3758.
Wilson, R. et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Nature (1994) 368:32-38. (GI 297956; GI 297965).
Berks, M. (GI 297956), GenBank Sequence Database (Accession Z22179), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Watanabe, T.K. et al., "Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegens." Cytogenet. Cell Genet. (1996) 74:146-148.

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