U-PA mutants resistant to inhibition by their cognate inhibitors

Details U-PA mutants resistant to inhibition by their cognate inhibitors U-PA mutants resistant to inhibition by their cognate inhibitors

1996-05-21

1998-03-17

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351721, 4351723, 536 232, 935 10, 935 14, C12N 972, C12N 1500, C07H 2104

Patent

active

057285640

ABSTRACT:
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.

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