Tyrosylprotein sulfotransferases and methods of use thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

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C435S069100, C435S069200, C435S193000, C536S023200

Reexamination Certificate

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11336497

ABSTRACT:
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse andC. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.

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