Tyrosylprotein sulfotransferases and methods of use thereof

Details Tyrosylprotein sulfotransferases and methods of use thereof Tyrosylprotein sulfotransferases and methods of use thereof

2006-04-18

2006-04-18

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S015000, C435S252300, C435S320100, C536S023200, C536S023500

Reexamination Certificate

active

07029890

ABSTRACT:
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse andC. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system. The enzymes can be used to sulfate peptides or proteins requiring sulfation.

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