Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-04-18
2000-06-06
Priebe, Scott D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4353201, 435325, 4352523, 43525411, 435 691, 435 701, 435455, 435471, 536 237, A61K 4800, C07H 1200, C12N 1531, C12N 121
Patent
active
060718927
ABSTRACT:
The invention provides tyrS polypeptides and DNA (RNA) encoding tyrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tyrS polypeptides to screen for antibacterial compounds.
REFERENCES:
Ben-Yedidia et al., "Design of peptide and polypeptide vaccines", Curr. Opin. Biotechnol. 8: 442-448, 1997.
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) pp. 1681-1690 (1996).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Henkin et al., "Analysis of the Bacillus subtilis tyrS Gene: Conservation of a Regulatory Sequence in Multiple tRNA Synthetase Genes,", J. Bacteriol, 174(4) pp. 1299-1306 (1992).
Barker et al., "The Tyrosyl-tRNA Synthetase from Escherichia coli, "FEBS Letters, 150(2) pp. 419-423 (1982).
Von Den Haar et al., "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets, " Angewandte Chemie, 20(3) pp. 217-302 (1981).
Minnel et al., "Aminoacyl-tRNA Synthetases: Occurrence, Structure, and Function. IN: tRNA: Structure, Biosynthesis and Function," American Society of Microbiology, pp. 251-292 (1995).
Hodgson John Edward
Lawlor Elizabeth Jane
Deibert Thomas S.
Gimmi Edward R.
King William T.
Priebe Scott D.
SmithKline Beecham Corporation
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