Tyrosyl derivatives and their use as P2X7 receptor modulators

Details Tyrosyl derivatives and their use as P2X7 receptor modulators Tyrosyl derivatives and their use as P2X7 receptor modulators

2006-08-22

2006-08-22

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S360000, C544S363000, C544S364000, C544S387000, C544S391000

Reexamination Certificate

active

07094895

ABSTRACT:
The present invention relates to compounds of the formulawherein R1and R2are independently hydrogen, C1–C4 alkyl, C1–C4 substituted alkyl, C1–C4 alkoxy, C1–C4 substituted alkoxy, C1–C4 acyl, halogen, cyano, nitro, amino, alkylamino, or dialkylamino;R3, R4, R5, R6, R7, and R8are independently CH or nitrogen;R9is hydrogen or methyl;R10is C═O or (CH2)n;where n is 0, 1, 2, 3, or 4;R11and R12are independently nitrogen or CH; X1and X2are independently hydrogen, deuterium, tritium or halogen; and X3is N; and their pharmaceutically acceptable salts; compositions thereof. Methods of preparing the compounds are also described. The compounds are useful in the treatment of diseases in mammals that are mediated by the action of the P2X7receptor.

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