Tyrosyl-class antigenic conjugates, their preparation and antibo

Details Tyrosyl-class antigenic conjugates, their preparation and antibo Tyrosyl-class antigenic conjugates, their preparation and antibo

1974-03-18

1976-08-17

Turner, V. D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260 78A, 260112B, 2601125R, 260121, 424 8, 424 12, 424 85, 424 88, 424177, A61K 3700, C07C10352, C07G 6936, G01N 3100

Patent

active

039753425

ABSTRACT:
Tyrosyl, thyronine, and histidyl compounds of the formulas: ##SPC1##
Where R' is selected from the group consisting of --OH and --NHP.sub.p and R" is selected from the class consisting of --H and --COP.sub.p, where P.sub.p is a polypeptide chain having from 1 to 250 peptide groups, with or without pendant groups, X is selected from the class consisting of H and I; when X is I, X' is selected from the group consisting of H and I; and n is 0 or 1, where X' is H when n is 0; are conjugated to a carrier by first forming a primary aromatic amine on the carrier, diazotizing the amine, and coupling the tyrosyl, histidyl, or thyronine through the diazo group to form a novel antigenic conjugate. This novel antigenic conjugate can be injected into an animal for production of specific antibodies which are useful in assaying for the target, particularly by radioassaying.

REFERENCES:
patent: 3809782 (1974-05-01), Spector
gross, Immunochem., vol. 5, 1968, pp. 55-65.
Spector, Advances in Biochem. Psychopharm., vol. 1, 1969, pp. 181-190.
Churchill, Nature, vol. 202, 1964, pp. 29-31.
Peskar, Science, vol. 179, Mar. 30, 1973, pp. 1340-1341.

Affiliated with

Also associated with

Rating

Tyrosyl-class antigenic conjugates, their preparation and antibo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tyrosyl-class antigenic conjugates, their preparation and antibo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tyrosyl-class antigenic conjugates, their preparation and antibo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1485271