Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-09-29
2000-03-21
Huff, Sheela
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, 4353201, 435 691, C07H 2102
Patent
active
06040437&
ABSTRACT:
This invention concerns new PSTPIP polypeptides which are bound by and dephosphorylated by the PEST family of protein tyrosine phosphatases. The invention specifically concerns native murine PSTPIP polypeptides and their homologues in other mammals, and their functional derivatives. The invention further relates to nucleic acids encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Methods for inducing the polymerization of actin monomers in eukaryotic cells and assays for identifying antagonists and agonists of the PSTPIP polypeptides of the present invention are also provided.
REFERENCES:
Marra et al, Database Genbank, subsection EST Accession No. AA038079, Aug. 1996.
Kitts, Database EMBL, Accession No. U13188, Mar. 1996.
Aoki et al., "The novel protein-tyrosine phosphatase PTP20 is a positive regulator of PC12 cell neuronal differentiation" Journal of Biological Chemistry 271(46):29422-29426 (1996).
Astier et al., "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after .beta.1-integrin stimulation in B cells and binds to p130cas" Journal of Biological Chemistry 272(1):228-232 (1997).
Charest et al., "Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST" Journal of Biological Chemistry 271(14):8424-8429 (1996).
Cheng et al., "A novel protein tyrosine phosphatase expressed in lin lo CD34 hi Sca hi hematopoietic progenitor cells" Blood 88(4):1156-1167 (1996).
Cloutier et al., "Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells" EMBO Journal 15(18):4909-4918 (1996).
Dixon, J., "Protein Tyrosine Phosphatases: their roles in single transduction" Recent Prog. Hom. Res. 51:405-414 (1996).
Dosil et al., "Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells" Blood 88(12):4510-4525 (1996).
Fantl et al., "Signalling by Receptor Tyrosine Kinases" Annual Review in Biochemistry 62:453-481 (1993).
Garton et al., "Identification of p130cas as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST" Molecular & Cellular Biology 16(11):6408-6418 (1996).
Huang et al., "Cloning and characterization of PTK-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow" Oncogene 13:1567-1573 (1996).
Hunter 1001 Protein Kinases Redux toward 2000 5:367-376 (1994).
Kim et al., "Characterization of the PEST family protein tyrosine phosphatase BDP1" Oncogene 13:2275-2279 (1996).
Matthews et al., "Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences" Molecular and Cellular Biology 12(5):2396-2405 (1992).
Petch et al., "Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate" J. Cell. Sci. 108:1371-1379 (1995).
Tonks, N., "Introduction: Protein tyrosine phosphatases" Semin. Cell Biol. 4:373-377 (1993).
Yang et al., "Cloning and expression of PTP-Pest. A novel, human, nontransmembrane protein tyrosine phosphatase" Journal of Biological Chemistry 268(23):17650 (1993).
Campbell, A., "General Properties and applications of monoclonal antibodies" Monoclonal Antibody Technology, The Netherlands:Elsevier Science Publishers B.V., Chapter 1, pp. 1-32 (1984).
Chevray et al., "Protein interaction cloning in yeast: identification of mammalian proteins that react with the Leucine Zipper of Jun" Proc. Natl. Acad. Sci. USA 89:5789-5793 (1992).
Chien et al., "The Two-Hybrid System: A method to identify and clone genes for proteins that interact with a protein of interest" Proc. Natl. Acad. Sci. USA 88:9578-9582 (1991).
Fankhauser et al., "The S. pombe cdc15 Gene Is a Key Element in the Reorganization of F-Actin at Mitosis" Cell 82:435-444 (1995).
Fields and Song, "A novel genetic system to detect protein-protein interactions" Nature 340:245-246 (1989).
Spencer et al., "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase" Journal of Cell Biology 138(4):845-860 (Aug. 25, 1997).
Wu et al., "Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein" Journal of Biological Chemistry 273(10):5765-5770 (Mar. 6, 1998).
Dowbenko Donald J.
Lasky Laurence A.
Genentech Inc.
Huff Sheela
Kresnak Mark T.
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