Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound other than saccharide containing a...
Patent
1996-05-10
1998-09-29
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound other than saccharide containing a...
435 697, 4352523, 4353201, 435325, 530300, 530350, 536 231, 536 235, C12P 2106
Patent
active
058144781
ABSTRACT:
The present invention provides for a gene, designated as musk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated and purified polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.
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Bowen David C.
Glass David J.
Valenzuela David M.
Yancopoulos George D.
Cobert Robert J.
Regeneron Pharmaceuticals Inc.
Sorensen Kenneth A.
Walsh Stephen
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