Tyrosine kinase inhibitors and benzoylacrylamide derivatives

Details Tyrosine kinase inhibitors and benzoylacrylamide derivatives Tyrosine kinase inhibitors and benzoylacrylamide derivatives

1994-01-25

1997-04-08

Wu, Shean C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546304, 546329, 546340, 546344, 546346, A01N 4340, A61K 3144, C07D21360, C07D21375

Patent

active

056188293

ABSTRACT:
A pharmaceutical composition which comprises a pharmaceutically effective amount of a compound of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom,
R.sup.2 represents --(CH.sub.2).sub.m -A
wherein m is an integer of 0 to 3, and
A represents pyridyl which is unsubstituted or is substituted by C.sub.1 -C.sub.3 alkyl said alkyl being unsubstituted or substituted by phenyl, and R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently represent a hydrogen atom, a halogen atom, C.sub.1 -C.sub.5 alkyl which is unsubstituted or is substituted with a halogen atom or --OR.sup.13 wherein R.sup.13 represents a hydrogen atom or C.sub.1 -C.sub.5 alkyl which is unsubstituted or is substituted with a halogen atom or phenyl, or when their adjacent substituents are taken together, they represent C.sub.1 -C.sub.3 oxyalkylene having one or two oxygen atoms;
or a pharmaceutically acceptable salt thereof, and
a pharmaceutically acceptable carrier therefor.

REFERENCES:
Caplus 1991:101537 (Mongelli et al, EP 388948 Sep. 26, 1990).

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