Tyrosine kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S254020, C514S370000, C546S209000, C544S369000, C548S190000

Reexamination Certificate

active

10486574

ABSTRACT:
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

REFERENCES:
patent: 3734923 (1973-05-01), Dowding et al.
patent: 3755347 (1973-08-01), Guillot et al.
patent: 6596746 (2003-07-01), Das et al.
patent: 451 156 (1968-05-01), None
patent: 0 069 784 (1982-05-01), None
patent: 0 069 784 (1987-12-01), None
patent: 0 928 790 (1999-07-01), None
patent: 7.428 (1969-12-01), None
patent: 2 252 808 (1975-06-01), None
patent: WO95 09852 (1995-04-01), None
patent: WO99 62890 (1999-12-01), None
patent: WO 00 02871 (2000-01-01), None
patent: WO 00 26203 (2000-05-01), None
patent: WO 01 17995 (2001-03-01), None
patent: WO 02 45652 (2002-06-01), None
patent: WO 03 000687 (2003-01-01), None
patent: WO 03 015717 (2003-02-01), None
Obach R.S., Drug-drug interactions; An important negative attribute in drugs, Durgs of Today, 39(5), 301-38, (2003).
Diabetic Retinopathy [online], [retrieved on Nov. 16, 2006]. Retrieved from the Internet, URL: http:http://www.nei.nih.gov/health/diabetic/retinopathy.asp.
Golub et al, Oct. 15, 1999, Science, 286, 531-537.
Hortobagyi, G., Oct. 1, 1998, N Engl J Med, 339, 974-984.
Drack, Preventing Blindness in Premature Infants, May 28, 1998, N. Engl. J. Med, 338(22), 1619-1621.
Lee et al, Brain tissue responses to ischemia, Sep. 2000, Journal of Clinical Investigation, 106(6), 723-731.
J. Rak et al. Cancer Research, 55:4575-4580, 1995.
G. Gasparini and A.L. Harris, J. Clin. Oncol., 1995, 13:765-782.
M. Toi et al., Japan. J. Cancer Res., 1994, 85:1045-1049.
A.J. Dickinson et al., Br. J. Urol., 1994, 74:762-766.
L.M. Ellis et al., Surgery, 1996, 120(5):871-878.
J.K. Williams et al., Am. J. Surg., 1994, 168:373-380.
A. Amirkhosravi et al., Platelets, 10:285-292 (1999).
S.P. Gunningham, et al., Can. Research, 61: 3206-3211 (2001).
A. Giatromanolaki et al., J. Pathol. 2001; 194:101-108.
Michael Detmar, J. Dermatological Sci., 24 Suppl. 1, S78-S84 (2000).
Hasegawa et al., Skeletal Radiol., vol. 28, pp. 41-45, 1999.
Brockelsby et al., Laboratory Investigation 79:1101-1111 (Sep. 1999).
Paul et al., Nature Med 7:222-227 (2001).
Matsuyama et al., J. Neurol. Sci. 186:75-79 (2001).
van der Flier et al., J. Infectious Diseases, 183:149-153 (2001).
Stephen K. Smith, Trends in Endocrinology & Metabolism, vol. 12, No. 4, pp. 147-151, May/Jun. 2001.
Levis et al., Blood, vol. 98, No. 3, pp. 885-887 (2001).
Rajesh K. Jain, Nature Medicine, vol. 7. No. 9, pp. 987-989 (Sep. 2001).
Giulio Jori, Lasers Med. Sci., 1990; 5: 115-120.
Chuannong Zhou, J. Photochem. and Photobiol. 1989; 3: 299-318.
Hendrich et al., Knee Surg Sports Traumatol Arthroscopy 5: 58-63 (1997).
Hall et al., Am J Hum Genet 61:785-789, 1997.
Li et al., Gene Therapy, 1998; 5:1105-13.
Fathallah-Shaykh et al., J Immunol 2000; 164:217-222.
Dougherty et al., J. Natl. Cancer Inst., 1998, 90(12): 889-905.
Van Bruggen et al., J. Clin. Invest,. 104:1613-1620 (1999).
Gerber et al., Nature Medicine, vol. 5, No. 6, pp. 623-628, 1999.
David A. Greenberg, Drug News Perspect 11(5):265-270 (1998).
Nakagawa et al., FEBS Let. 473:161-164 (2000).
Peter Traxler, Exp. Opin. Ther. Patents 8 (12) 1599-1625(1998).
Peter M. Traxler, Exp. Opin. Ther. Patents 7(6) 571-588 (1997).
Joseph V. Simone, Cecil Textbook of Medicine 20th Edition, vol. 1, pp. 1004-1010 (1996).
Lawrence et al., Pub Med Abstract, vol. 77(2), pp. 81-114 (1998).
Cuckler, et al., Nithiazide I. Chemical and Biological Studies, vol. 92, pp. 483-488 (1956).
Nagano, et al., Studies on Organic Sulfur Compounds, vol. 21, pp. 2408-2416 (1973).
Werbel, et al., Journal of Medicinal Chemistry, vol. 15, No. 9 pp. 955-963 (1972).
Micich, et al., Journal of the American Oil Chemists' Society, vol. 59, No. 10 pp. 448-452 (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tyrosine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tyrosine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tyrosine kinase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3762380

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.