Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-10-14
1995-09-05
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 43525411, 4353201, 435194, 536 232, 536 235, C12N 510, C12N 1554, C12N 115, C12N 121, C12N 1563
Patent
active
054478600
ABSTRACT:
A novel receptor protein tyrosine kinase named ork (orphan receptor tyrosine kinase) is identified and characterized. cDNA encoding the ork protein is inserted into an expression vector for production of the protein via recombinant DNA technology. The ork cDNA, when transfected into Cos-7 cells, encodes a 140 Kd protein with in vitro kinase activity. The ork gene is expressed predominantly in placenta and lung, with lower levels in umbilical vein endothelial cells, brain and kidney.
REFERENCES:
Ziegler et al (1993) Oncogene 8:663-670.
Flanagan et al. (1990) Cell 63 185-194.
Partanen et al., "Putative tyrosine kinases expressed in K-562 human leukemia cells" Proc. Natl. Acad. Sci. USA 87:8913-8917, 1990.
Partanen et al., "A Novel Endothelial Cell Surface Receptor Tyrosine Kinase with Extracellular Epidermal Growth Factor Homology Domians" Mol. Cell. Biol. 12:1698-1707, 1992.
Wilks, "Tow putative protein-tyrosine kinases identified by application of the polymerase chain reaction" Proc. Natl. Acad. Sci. USA 86:1603-1607, 1989.
Yarden and Ullrich, "Growth Factor Receptor Tyrosine Kinases" Ann. Rev. Biochem. 57:443-78, 1988.
Hirai et al., "A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene" Science 238:1717-1720, 1987.
Lindberg and Hunter, "cDNA Cloning and Characterization of eck, and Epithelial Cell Receptor Protein-Typrosine Kinase in the eph/elk Family of Protein Kinases" Mol. Cell. Biol. 10:6316-6324, 1990.
Hanks et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains" Science 241:42-52, 1988.
Ullrich and Schlessinger, "Signal Transduction by Receptors with Tyrosine Kinase Activity" Cell 61:203-212, 1990.
O'Bryan et al., "axl, a Transforming Gene Isolated from Primary Human Myeloid Leukemia Cells, Encodes a Novel Receptor Tyrosine Kinase" Mol. Cell. Biol. 11:5016-5031, 1991.
Rescigno et al., "A putative receptor tyrosine kinase with unique structural topology" Oncogene 6:1909-1913, 1991.
Lhotak et al., "Characterization of Elk, a Brain-Specific Receptor Tyrosine Kinase"Mol. Cell. Biol. 11:2496-2502, 1991.
Chan and Watt, "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases" Oncogene 6:1057-1061, 1991.
Sasaki et al., "Laminin, a Multidomain Protein" J. Biol. Chem. 263:16536-16544, 1988.
Ellisen et al., "TAN-1, the Human Homolog of the Drosophila Notch Gene, Is Broken by Chromosomal Translocations in T Lymphoblastic Neoplasms" Cell 66:649-661, 1991.
Williams and Barclay, "The Immunoglobulin Superfamily-Domains for Cell Surface Recognition" Ann. Rev. Innumol. 6:381-405, 1988.
Takahashi and Cooper, "ret Transforming Gene Encodes a Fusion Protein Homologous to Tyrosine Kinases" Mol. Cell. Biol. 7:1378-1385, 1987.
Margolis et al., "EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signaling" Cell 57:1101-1107, 1989.
Terman et al., "Identification of a new endothelial cell growth factor receptor tyrosine kinase" Oncogene 6:1677-1683, 1991.
Aprelikova et al., "FLT4, a Novel Class III Receptor Tyrosine Kinase in Chromosome 5q33-qter" Cancer Research 52:746-748, 1992.
Matthews et al., "A Receptor Tyrosine Kinase Specific to Hematopoietic Stem and Progenitor Cell-Enriched Populations" Cell 65:1143-1152, 1991.
Reid et al., "Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain" Proc. Natl. Acad. Sci. USA 87:1596-1600, 1990.
Raz et al., "PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors" Oncogene 753-760, 1991.
Lai and Lemke, "An Extended Family of Protein-Tyrosine Kinase Genes differentially Expressed in the Vertebrate Nervous System" Neuron 6:691-704, 1991.
Anderson Kathryn A.
Bugaisky G. E.
Immunex Corporation
Patterson Jr. Charles L.
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