Tyrosine-containing cyclophilin and related methods

Details Tyrosine-containing cyclophilin and related methods Tyrosine-containing cyclophilin and related methods

1998-02-24

2000-11-21

Housel, James C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530333, 530412, C07K 100

Patent

active

061505013

ABSTRACT:
The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.

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