Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1993-04-02
1995-11-14
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
514557, 514762, 514947, A61K 31045, A61K 3101, A61K 3119
Patent
active
054667186
ABSTRACT:
Methods and compositions are provided for inhibiting the activity of tyrosinase in a host and, as a result, inhibiting melanin-formation. The tyrosinase-inhibitor active ingredient is a compound or mixture of compounds represented by the following structural formulae (I) and (II): ##STR1## wherein the dotted lines at a, b, c, d, e, f, g, represent an optional double bond, provided that double bonds are not at both b and c, or at both f and g, at the same time; R.sup.1, R.sup.5, R.sup.6, and R.sup.7 are each hydrogen or methyl; R.sup.2 and R.sup.8 are each no group, or each hydrogen or hydroxyl when there is no double bond at a and at f, respectively; R.sup.3 is methylene when there is a double bond at b, or hydrogen or methyl when there is no double bond at b; R.sup.4 is formyl or --(CH.sub.2).sub.n --R.sup.10, wherein R.sup.10 is hydrogen, hydroxyl, acyloxy, or cyano and n is an integer of from 1 to 3; and R.sup.9 is methylene when there is a double bond at g, or --(CH.sub.2).sub.n --R.sup.10 when there is no double bond at g.
REFERENCES:
patent: 4052515 (1977-10-01), McDermott et al.
patent: 4853413 (1989-08-01), Katz et al.
The Merck, Index, 10th Ed. (1983) p. 332, abstract No. 2302.
CA (13:29295n) 1989.
Chemical Abstracts 113(4):29294m 1989.
Huang Jiansheng
Kang Kok Lean R.
McAlister Kelly L.
Nakatsu Tetsuo
Henley III Raymond
Takasago Institute for Interdisciplinary
Weddington K.
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