Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2003-05-19
2009-12-08
Le, Emily M. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
Reexamination Certificate
active
07629116
ABSTRACT:
A method for determining the presence of a viral infection in an animal not known to have been infected with a virus or other disease-causing microbial organism by determining the level of Mx protein or other Type I Interferon-inducible protein in the animal.
REFERENCES:
patent: 5175113 (1992-12-01), Nissen
patent: 5194245 (1993-03-01), Carter
patent: 5198350 (1993-03-01), Horisberger et al.
patent: 5466585 (1995-11-01), Horisberger et al.
patent: 5739290 (1998-04-01), Horisberger et al.
patent: 5776690 (1998-07-01), Vojdani
patent: 5863742 (1999-01-01), Oh
patent: 5869264 (1999-02-01), Horisberger et al.
patent: 6030785 (2000-02-01), Katze
patent: 6180102 (2001-01-01), Hanai et al.
patent: 6200559 (2001-03-01), von Wussow
patent: 2002/0192838 (2002-12-01), Ott
patent: 2003/0027176 (2003-02-01), Dailey
patent: 2004/0209800 (2004-10-01), Mushinski et al.
patent: 0 725 081 (2003-01-01), None
patent: 1 489 416 (2004-12-01), None
Fields. Fields Virology. Lippincott Williams & Wilkins Publishers; Aug. 2001, p. 340-342.
Von Wussow et al. The interferon-induced Mx-homologous protein in people with symtomatic HIV-1 infection. AIDS 1990, vol. 4, p. 119-124.
Rump et al. Common variable immunodeficiency (CVID) and MxA-protein expression in blood leucocytes. Clin. Exp. Immunol. 1995, vol. 101, p. 89-93.
Roers et al. MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. The Journal of Infectious Diseases, 1994, vol. 169, p. 807-813.
Chieux et al. The MxA protein levels in whole blood lysaates of patients with various viral infections. Journal of Virological Methods, 1998, vol. 70, 183-191.
Charleston, B. and Stewart, H. J. (1993) “An interferon-induced Mx protein: cDNA sequence and high level expression in the endometrium of pregnant sheep” Gene 137:327-331.
U.S. Appl. No. 60/329,740.
Chieux et al. The MxA protein levels in whole blood lysates of patients with various viral infections. Journal of Virological Methods, 1998, vol. 70, pp. 183-191.
Muller-Doblies et al. Innate immune responses of calves during transient infection with a noncytopathic strain of bovine viral diarrhea virus. Clinical and Diagnostic Laboratory Immunology. Mar. 2004, vol. 11, No. 2, 302-312.
Chieux et al. The MxA protein levels in whole blood lysaates of patients with various viral infections. Journal of Virological Methods, 1998, vol. 70, 183-191.
Charleston, B. and Stewart, H. J. (1993) “Aan interferon-induced Mx protein: cDNA sequence and high level expression in the endometrium of pregnant sheep” Gene 137:327-331.
U.S. Appl. No. 60/329,740, (2001).
Bazzigher, L, et al., “Mx genes show weaker primary response to virus than other interferon-regulated genes”, Virology, 186:154-160 (1992).
Chieux , V et al., “The MxA protein levels in whole blood lysates of patients with various viral infections”, J. of Virological Methods, 70:183-191 (1998).
Fernandez, M, et al., “In vivo and in vitro induction of MxA protein in peripheral blood mononuclear cells from patients chronically infected with Hepatitis C Virus”, J. of Infectious Diseases, 180:262-267 (1999).
Forster, J, et al., “MxA protein in infants and children with respiratory tract infection”, Acta Paediatr, 85:163-167 (1996).
Haller, O, et al., “Mx proteins: mediators of innate resistance to RNA viruses”, Rev. Sci. Tech. Off. Int. Epiz. 17(1):220-230 (1998).
Halminen, M, et al, “Expression of MxA protein in blood lymphocytes discriminates between viral and bacterial infections in febrile children”, Pediatric Research, 41(5):647-650 (1997).
Muller-Doblies, D, et al, “In vitro and in vivo detection of Mx gene products in bovine cells following stimulation with alpha/beta interferon and viruses”, Clinical and Diagnostic Laboratory Immunology, 9(6):1192-1199 (Nov. 2002).
Nieforth, Ka, et al., “Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects”, Clin. Pharmacol. Ther., 59:636-646 (1996).
Oh, Sk, et al., “Quantitation of interferon-induced Mx protein in whole blood lysates by an immunochemiluminescent assay: elimination of protease activity of cell lysates in toto”, J. of Immunological Methods, 176:79-91 (1994).
Roers, A, et al., “MxA gene expression after live virus vaccination: a sensitive marker for endogenous Type I Interferon”, J. of Infectious Diseases, 169:807-813 (1994).
Rump, Ja, et al., “Common variable immunodeficiency (CVID) and MxA-protein expression in blood leucocytes”, Clin. Exp. Immunol., 101:89-93 (1995).
Von Wussow, et al., “The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection”, AIDS, 4:119-124 (1990).
Horisberger and Staritzky, “Expression and Stability of the Mx Protein in Different Tissues of Mice, in Response to Interferon inducers or to influenza virus infection.”, J. Interferon Res., 9:583-590 (1989).
Halminen, M, et al, “Expression of MxA Protein in Blood Lymphocytes Discriminates between Viral and Bacterial Infections in Febrile Children.”, Pediatric Research, 41(5):647-650 (1997).
Eisenberg, Esq. Howard
Idaho Research Foundation
Le Emily M.
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