Tylosin derivatives and their manufacturing process

Details Tylosin derivatives and their manufacturing process Tylosin derivatives and their manufacturing process

1976-07-23

1978-05-30

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

195 80R, 424181, 536 4, 536 9, A61K 3171, C07H 1708

Patent

active

040924734

ABSTRACT:
New tylosin derivatives having at least one acyl group at the 3- and 4"-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4"-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.

REFERENCES:
patent: 3424743 (1969-01-01), Uzu et al.
patent: 3853842 (1974-12-01), Kishi et al.
Mazurczak et al., vol. 81, 1974 "Chem. Abst." p. 10156s.
Thomas et al., "Chem. Abst." vol. 81, 1974, p. 103,539j.

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