Tylosin derivatives

Details Tylosin derivatives Tylosin derivatives

1981-07-22

1984-03-20

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 71, A61K 3170, C07H 1708

Patent

active

044381093

ABSTRACT:
Tylosin derivatives shown by the general formula ##STR1## wherein R represents a hydrogen atom or a hydroxyl group; R.sub.1 represents a halogen atom, a hydroxyl group, a tetrahydrofuranyloxy group, a tetrahydropyranyloxy group, a tetrahydrothiofuranyloxy group, a tetrahydrothiopyranyloxy group, an alkanoyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, a lower alkylthiomethyloxy group, a heterocyclic thio group which may have a substituent, a mono- or di- lower alkylamino lower alkylthio group or a group of ##STR2## (wherein R.sub.4 represents a hydroxyl group or an alkanoyloxy group); R.sub.2 represents a hydrogen atom, a hydroxyl group, or an alkanoyloxy group; R.sub.3 represents a hydroxyl group or an alkanoyloxy group; and represents a single bond or a double bond, but represents a double bond when R.sub.2 is a hydrogen atom.
These compounds are useful as antibiotics.

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Tanaka, et al., "Bull. Chem. Soc. Japan", vol. 54, 1981, pp. 3837-3845.
Tanaka et al., "Jour. of Antibiotics", vol. 34, 1981, pp. 1374-1376, 1377-1380.
Omura, "Durwent Abstracts", 82541D/45 of Japanese Kokai J56122-397, 9/1981.

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