Tylosin derivatives

Details Tylosin derivatives Tylosin derivatives

1978-10-23

1980-05-27

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 9, A61K 3171, C07H 1708

Patent

active

042051630

ABSTRACT:
A number of 4"-acyl derivatives of tylosin and acetyltylosin which are prepared by first protectively acylating at the 2'-hydroxyl group of tylosin or acetyltylosin, secondly at the 4'"-hydroxyl group thereof, thirdly at the 4"-hydroxyl group thereof and finally deacylating the 2'- and 4'"-acyl groups to produce new 4"-acyl derivatives of tylosin or acetyltylosin which effect high blood level compared to those tylosin derivatives heretofore are disclosed.

REFERENCES:
patent: 4092473 (1978-05-01), Okamoto et al.

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