Tylosin biosynthetic genes tylA, tylB and tylI

Details Tylosin biosynthetic genes tylA, tylB and tylI Tylosin biosynthetic genes tylA, tylB and tylI

1991-07-30

1992-09-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 72, 435 91, 435169, 4351723, 43525233, 43525235, 4353201, 4352523, 536 27, C12P 1962, C12P 1934, C12N 121, C12N 1552

Patent

active

051496380

ABSTRACT:
Provided are gene sequences encoding tylosin biosynthetic gene products. In particular, recombinant DNA vectors comprising DNA sequences encoding the tylA, tylB, tylI and tylG activities of Streptomyces fradiae are provided. Also provided are host cells transformed with the noted vectors and a method for increasing the tylosin-producing ability of a tylosin-producing organism.

REFERENCES:
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Baltz et al., 1982, Genentics and Biochemistry of Tylosin Production in Trends in Antibiotic Research (eds. Unezawa et al.; published by the Japan Antibiotics Research Association).
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De Main, 1985, Nature 314:577-578.
Seno and Hutchinson, 1986, The biosynthesis of tylosin and erythromycin: model system for studies of the genetics and biochemistry of antibiotic formation, in The Bacteria, A Treatise on Structure and Function, (eds. J. R. Sokatch and L. N. Ornston), vol. IX, Antibiotic-Producing Streptomyces (vol. eds: S. W. Queener and L. E. Day), Academic Press, Inc., Orlando, FL, pp. 231-279.
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