Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical co

Details Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical co Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical co

1982-06-10

1984-03-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 71, A61K 3171, C07H 1708

Patent

active

044353880

ABSTRACT:
There are disclosed 20-imino-20-deoxo-4"-acyl derivatives of the antibiotic tylosin which have higher serum levels and better absorption than the parent tylosins. Methods of preparation of the compounds are also disclosed.

REFERENCES:
patent: 4268665 (1981-05-01), Sakakibara et al.
patent: 4279896 (1981-07-01), Ganguly et al.
Tsuchiya et al., "The Jour. of Antibiotics", vol. XXXV, No. 6, pp. 661-672, 1982.
Toju et al., "Drug Action and Drug Resistance in Bacteria" Univ. of Tokyo Press, Tokyo, Japan, 1971, pp. 284-287.
Derwent Abstract-Japanese Pat. #J56147-798, 3/31/80.
Derwent Abstract-European Patent #45-157, 7/24/80.

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