Two-step pretargeting methods using improved biotin-active agent

Details Two-step pretargeting methods using improved biotin-active agent Two-step pretargeting methods using improved biotin-active agent

1993-09-16

1997-05-20

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 153, 424 9363, 5483037, 5483041, 548520, 548526, 514387, 540474, 5303915, 5303913, 5303911, 5462831, 5462787, A61K 5110, A61K 31415, C07K 1630, C07D25702

Patent

active

056309961

ABSTRACT:
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.

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