Two stage calibration and analyte measurement scheme for spectro

Details Two stage calibration and analyte measurement scheme for spectro Two stage calibration and analyte measurement scheme for spectro

1997-04-09

1999-04-06

Hindenburg, Max

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

356 41, A61B 500

Patent

active

058910247

ABSTRACT:
A two-stage statistical calibration and measurement method and system is disclosed for performing photoplethysmographic measurement of blood analyte concentrations. Concentrations in a tissue sample of MetHb, O.sub.2 Hb, RHb and COHb are estimated by first estimating a concentration of MetHb (in a first stage) and subsequently, if the concentration of MetHb is within a predetermined range, then the estimated concentration of MetHb is assumed to be accurate and this estimated concentration of MetHb is utilized as a "known value" in determining the concentrations of the remaining analytes O.sub.2 Hb, RHb and COHb (in a second stage). That is, by eliminating one "unknown" from the system of equations, these remaining analytes can be calculated with increased accuracy. Each stage is performed using data obtained by transmitting light through the tissue sample (typically a finger or earlobe). The transmitted light is generated by four discrete light emitters, each emitter having a distinct spectral content.

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