Two-phase matrix for sustained release drug delivery device

Details Two-phase matrix for sustained release drug delivery device Two-phase matrix for sustained release drug delivery device

1993-04-30

1999-11-23

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, 424447, 424448, A61F 1300, A61F 1302, A61F 970

Patent

active

059895861

ABSTRACT:
A two-phase hydrophilic drug-containing matrix for use in transdermal drug delivery patches in which one phase is a continuous hydrophobic polymer phase which optionally includes a hydrophobic solvent that acts as a skin permeation enhancer and the other phase is a dispersed particulate hydrated inorganic silicate in whose absorbed aqueous phase the drug is dissolved.

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Naoyaki Yoshida et al, "DAT-582 . . . " J of Pharmacology and Experimental Therapeutics, vol. 260, No. 3 pp. 1159-1165.

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