Two-phase formulation

Details Two-phase formulation Two-phase formulation

1984-05-02

1985-12-31

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

514356, 514772, 514781, 514784, 514788, 424 19, 424 22, A61K 3179, A61K 31455, A61K 4700

Patent

active

045620695

ABSTRACT:
In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.

REFERENCES:
patent: 4343789 (1982-08-01), Kawata et al.
patent: 4404183 (1983-09-01), Kawata et al.
patent: 4412986 (1983-11-01), Kawata et al.
Sugimoto et al., C.A. 95, #86250c (1981) of Chem. Pharm. Bull. 29(6): 1715-23, (1981).
Sugimoto et al., C.A. 96, #110072q (1982) of Iyakuhin Kenkyu 12(4): 988-992, (1981).
Sugimoto et al., C.A. 95, #53922d (1980) of Drug Dev. Ind. Pharm. 6(2): 137-160, (1980).
Sugimoto et al., C.A. 98, #132212d (1983) of Chem. Pharm. Bull. 30(12): 4479-88, (1982).

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