Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-07-01
2001-05-29
Jones, Dameron L. (Department: 1619)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S434000, C424S400000, C424S059000
Reexamination Certificate
active
06238680
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a cosmetic and/or dermatological composition consisting of an aqueous phase and a separate oily phase, where the composition contains at least one ammonium bromide, and preferably myristyltrimethylammonium bromide, as a preserving agent. The present invention also relates to the use of this composition for cleansing and/or removing make-up from the skin, mucous membranes and/or the eyes, and in particular for removing make-up from sensitive eyes.
2. Description of the Background
It is known practice to use compositions which are in the form of two separate phases and which become emulsified by shaking and demix on standing, for removing make-up from the eyes. Such a composition is described in, for example, in EP-A-370,856.
These compositions in two-phase form contain preserving agents, in particular quaternary ammonium chlorides such as benzalkonium chloride. However, these compounds occasionally entail tolerance problems, in particular in individuals with sensitive eyes. As a result, it is an important goal to replace these preserving agents with agents which are better tolerated.
In addition, the preserving agents usually used in compositions in the form of a single phase are often relatively incompatible with the two-phase pharmaceutical form, since these conventional preserving agents lead to physicochemical instabilities giving rise to the formation of a film or a precipitate in the aqueous phase, or else they greatly disturb the water/oil interface leading to an undesirable appearance of the two-phase composition.
There is thus a need to have available a two-phase position which stores well, without having the drawbacks of known compositions, i.e., a composition which has both a pleasant appearance and good stability.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a composition having enhanced stability, where the composition has two phases: an aqueous phase and a separate oily phase.
It is another object of the present invention to provide methods of cleansing and/or removing make-up from the skin, mucous membranes and/or the eyes using the composition described above.
The present inventors have unexpectedly discovered that the use of at least one ammonium bromide, and in particular an alkyltrimethylammonium bromide, provides stable two-phase compositions with good properties of both physicochemical and microbial storage, while at the same time allowing efficient make-up removal under highly satisfactory conditions of comfort and freshness. There was no indication that this preserving agent could be used successfully in two-phase compositions.
Accordingly, the objects of the present invention, and others, may be accomplished with a two-phase cosmetic and/or dermatological composition consisting of a separate aqueous phase and oily phase, where the composition also contains at least one ammonium bromide.
The objects of the invention may also be accomplished with a method of preserving a cosmetic composition comprising an aqueous phase and a separate oily phase, comprising incorporating an effective amount of an ammonium bromide, and in particular an alkyltrimethylammonium bromide into the composition.
The objects of the invention may also be accomplished with a method of cleansing and/or removing make-up from the skin, mucous membranes and/or the eyes, comprising applying the composition to the skin, mucous membranes and/or the eyes.
A more complete appreciation of the invention and many of the attendant advantages thereof will be readily obtained as the same becomes better understood by reference to the following detailed description.
DETAILED DESCRIPTION OF THE INVENTION
As ammonium bromides which can be used in the inventive composition alkyltrimethylammonium bromides are preferred. The alkyl radical of these compounds may contain from 1 to 22 carbon atoms and, more preferably, from 8 to 20 carbon atoms. These ranges include all specific values and subranges in between, including 2, 3, 5, 10, 12 and 18 carbon atoms.
Ammonium bromides which can be used in the composition, include, for example, dodecyltrimethylammonium bromide, myristyltrimethylammonium bromide and hexadecyltrimethylammonium bromide, and mixtures thereof. Myristyltrimethylammonium bromide is preferred.
It is possible, for example, to use myristyltrimethylammonium bromide (CTFA name: Mytrimonium bromide) either in its native state or in a mixture containing it, and in particular in a mixture with other ammonium bromides, for example in the mixture of dodecyltrimethylammonium bromide, myristyltrimethylammonium bromide and hexadecyltrimethylammonium bromide, sold under the name Cetrimide by FEF Chemicals.
The ammonium bromide is present in the composition of the invention in an amount which is sufficient to act as a preserving agent in the composition. Thus, this compound may be present in an amount ranging, for example, from 0.005 to 0.5% relative to the total weight of the composition, and preferably from 0.01 to 0.1% relative to the total weight of the composition. These weight % ranges include all specific values and subranges in between, such as 0.02, 0.05, 0.2, 0.3 and 0.4% by weight.
According to a preferred embodiment of the invention, the composition also contains, as an additional preserving agent, N-(3-chloroallyl)hexaminium chloride (CTFA name: quaternium-15), whose combination with a bromide is well tolerated and affords excellent preservative effect. The N-(3-chloroallyl)hexaminium chloride may be present in the composition of the invention in an amount ranging from 0 to 0.5% relative to the total weight of the composition, and preferably from 0.001 to 0.1% relative to the total weight of the composition. These ranges include all specific values and subranges therebetween, such as 0.002, 0.005, 0.01, 0.05, 0.2, 0.3 and 0.4% by weight.
The composition according to the invention comprises at least one aqueous phase (i.e., contains water) and a separate oily phase.
The aqueous phase in the composition of the invention may comprise sterile demineralized water and/or a floral water such as rose water, cornflower water, camomile water or lime water, or a thermal water or natural mineral water such as, for example: eau de Vittel, waters from the Vichy basin, eau d'Uriage, eau de la Roche Posay, eau de la Bourboule, eau d'Enghien-les-Bains, eau de Saint Gervais-les-Bains, eau de Neris-les-Bains, eau d'Allevar-les-Bains, eau de Digne, eau de Maizieres, eau de Neyrac-les-Bains, eau de Lons-le-Saunier, Eaux Bonnes, eau de Rochefort, eau de Saint Christau, eau des Fumades, eau de Tercis-les-bains and eau d'Avene. Mixtures of these waters may be used.
The oily phase in the composition according to the invention comprises at least one oil. The oil may be chosen from mineral, plant or synthetic oils or alternatively silicone oils, and mixtures thereof.
Among the mineral oils which may constitute the oily phase, preferable examples include liquid petroleum jelly and higher aliphatic hydrocarbons such as, for example, isohexadecane or isododecane; among the plant oils, jojoba oil and safflower oil; among the silicone oils, which may be volatile, cyclomethicones such as cyclopentadimethylsiloxane, and among the synthetic oils, alkyl palmitates in which the alkyl group contains from 2 to 10 carbon atoms, such as isopropyl palmitate or octyl palmitate, and alkyl adipates in which the alkyl group contains from 2 to 10 carbon atoms, such as bis(2-ethylhexyl) adipate, or any other aliphatic ester containing from 12 to 20 carbon atoms, and mixtures thereof.
According to one specific embodiment of the invention, the oily phase contains at least one oil chosen from alkyl palmitates, isohexadecane, isododecane, volatile silicone oils (cyclomethicones) and mixtures thereof.
When the composition contains an alkyl palmitate, the latter is preferably present in a proportion of at least 5% and better still in a proportion ranging from 8 to 30% of the total weight of the composition. Thes
Bui-Bertrand Lien
Picard Elisabeth
Jones Dameron L.
L'Oreal
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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