Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Phosphorus or phosphorus compound
Patent
1986-12-31
1989-06-06
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Phosphorus or phosphorus compound
514912, 424605, 424677, 424681, 424717, A61K 3300, A61K 3342, A61K 3314, A61K 3306
Patent
active
048370215
ABSTRACT:
A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium calcium chloride, and bicarbonate ions as well as dextrose, glutathione, and gamma-amino butyric acid (GABA) or functional analogue(s) of GABA, or a mixture of GABA and such analogue(s) in proportions consistent with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.
REFERENCES:
patent: 4443432 (1984-04-01), Garabedian et al.
patent: 4550022 (1985-10-01), Garabedian et al.
Vidal et al., "GABA Influences Rabbit Corneal Deturgescence" Chem Abst. 93:231294k, p. 106 (1980).
Dikstein, et al. "Corneal Endothelial Pumping in the Presence of Insulin and GABA", Exp. Eye Res., 31, 239-241 (1980).
Andermann Guy
de Burlet Georges
Dietz Michel
Spittler Joseph
Arno James A.
Brown Gregg C.
Henley III Raymond J.
Laboratoires P.O.S.
Robinson Douglas W.
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