Two-part oral products and methods of using same to remineralize

Details Two-part oral products and methods of using same to remineralize Two-part oral products and methods of using same to remineralize

1998-08-07

1999-01-12

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Phosphate compound containing

424 48, 424 49, 424 52, 424435, 424440, 106 35, A61K 716, A61K 718, A61K 965

Patent

active

058583335

ABSTRACT:
A two-part oral product capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth is composed of cationic and anionic discrete parts. The cationic discrete part contains at least one water-soluble calcium salt and, preferably, at least one non-toxic, water-soluble salt of a divalent metal other than calcium, and a first pharmaceutically acceptable carrier. The anionic discrete part contains at least one water-soluble phosphate salt and, preferably, at least one water-soluble fluoride salt, and a second pharmaceutically carrier. Preferably, one of the carriers is an aqueous carrier and the other of the carriers is a non-aqueous carrier. The cationic and anionic parts are simultaneously released from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution. In this way, calcium ions released by the calcium salt and phosphate ions released by the phosphate salt are simultaneously delivered to the tooth surfaces by the solution. To effect subsurface remineralization and/or mineralization, the parts are mixed together to form the mixed aqueous solution, and the solution is then promptly applied to the teeth for a period of time sufficient to allow calcium ions and phosphate ions to diffuse through the tooth surface to the subsurface, where the ions react to form an insoluble precipitate onto the lesion and/or tubule, thereby remineralizing such lesion and/or mineralizing such tubule.

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