Two-part medicinal tablet and method of manufacture

Details Two-part medicinal tablet and method of manufacture Two-part medicinal tablet and method of manufacture

1993-02-22

1995-02-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424467, 424468, 424473, 424474, A61K 920, A61K 924

Patent

active

053913787

ABSTRACT:
A medicinal tablet mechanical configuration is provided that permits prolonged absorption of a medicinal dosage through the gastro-intestinal tract of warm blooded animals. The tablet is formed with a solid core unit that contains the medically beneficial drug and an outer unit that maintains its physical and chemical integrity during the dosage life of the core unit. The medicinal tablet is formed in a die by first placing a quantity of powder from which the outer unit is formed into the die. The core unit is next positioned within the die so that portions of the surface of the core unit abut the die. The remainder of the powder to form the outer unit is then placed in the die and the contents of the die are subjected to a compressive force by die punches inserted into the die so that the tablet is formed. At the points where the core unit abuts the die, the core unit is exposed through the outer unit so that the drug in the core unit is released slowly rather than the entire surface of the core unit being exposed which would cause more rapid absorption of the drug in the intestinal tract.

REFERENCES:
patent: 4803076 (1989-02-01), Ranade
patent: 4816262 (1989-03-01), McMullen
patent: 4824677 (1989-04-01), Shah et al.
patent: 4842867 (1989-06-01), Ayer et al.

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