Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1998-05-18
1999-10-12
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435226, A61K 3846, C12N 964
Patent
active
059651296
ABSTRACT:
The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCPs. The invention also provides for the production and use of antibodies to HCPs in pharmaceutical compositions for the treatment of disease processes that include cancers, inflammation, metastasis and peptide and proenzyme processing. In addition, the invention provides for the production and use of inhibitors of HSPs in pharmaceutical compositions for the treatment of diseases. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HCPs. The invention also provides for the use of antisense molecules in pharmaceutical compositions as therapeutics in cancers, inflammation, metastasis and peptide and proenzyme processing.
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Bandman Olga
Coleman Roger
Incyte Pharmaceuticals Inc.
Price Leanne C.
Wax Robert A.
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