Two helix binders

Chemistry: analytical and immunological testing – Biospecific ligand binding assay

Reexamination Certificate

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C530S323000, C530S317000, C435S007230

Reexamination Certificate

active

07981691

ABSTRACT:
An isolated polypeptide, Z domain, derived from B domain ofStaphylococcalprotein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.

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