Chemistry: electrical and wave energy – Apparatus – Coating – forming or etching by sputtering
Patent
1993-03-09
1995-02-14
Niebling, John
Chemistry: electrical and wave energy
Apparatus
Coating, forming or etching by sputtering
2041801, G01N 2726, G01N 27447
Patent
active
053892216
ABSTRACT:
A combination liquid chromatography and capillary electrophoresis separation system is disclosed. The system comprises a flow gating interface having an effluent channel and a gating channel formed therein. The gating channel transversely intersects the effluent channel at an intersection portion so that the channels are in fluid communication with one another. The intersection portion divides the effluent channel into an upstream portion and a downstream portion, and divides the gating channel into an upstream portion and a downstream portion. A liquid chromatography column is connected to the effluent channel upstream portion and an electrophoresis capillary is connected to the effluent channel downstream portion. A flush solution inlet line is connected to said gating channel upstream portion, and a flush solution outlet line is connected to the gating channel downstream portion. A valve regulates the flow of flush solution from the flush solution inlet line to the gating channel upstream portion. The intersection portion is configured so that the rate of flow of effluent from the effluent channel upstream portion to the effluent channel downstream portion decreases as the rate of flow of flush solution in the gating channel increases.
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Stephen L. Pentoney, Jr. et al. "On-Line Connector for Microcolumns: Application of the On-Column .alpha.-Phthaldialdehyde Derivation of Amino Acids Separated by Capillary zone Electrophoresis" Analytical Chemistry vol. 60, No. 23 (Dec. 1988) 2625-2629.
P. Janssen et al., Journal of Chromatography 470, 171-183 (1989).
R. Nielsen et al., Journal of Chromatography 480, 393-401 (1989).
H. Yamamoto et al., Journal of Chromatography 480, 277-283 (1989).
Jorgenson James W.
Lemmo Anthony V.
Niebling John
Starsiak Jr. John S.
The University of North Carolina at Chapel Hill
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