Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2009-03-13
2011-11-01
Seaman, D M (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S249000, C514S299000, C546S121000, C544S105000, C544S349000
Reexamination Certificate
active
08048878
ABSTRACT:
The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I):whereinrepresents a single bond or a double bond; Ar1represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1and R2each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
REFERENCES:
patent: 4910200 (1990-03-01), Curtze et al.
patent: 5281626 (1994-01-01), Oinuma et al.
patent: 5563162 (1996-10-01), Oku et al.
patent: 5985856 (1999-11-01), Stella et al.
patent: 6235728 (2001-05-01), Golik et al.
patent: 6306870 (2001-10-01), Bombrun
patent: 7053087 (2006-05-01), Beatch et al.
patent: 7138414 (2006-11-01), Schoenafinger et al.
patent: 7300936 (2007-11-01), Parker et al.
patent: 7314940 (2008-01-01), Graczyk et al.
patent: 7618960 (2009-11-01), Kimura et al.
patent: 7667041 (2010-02-01), Kimura et al.
patent: 7687640 (2010-03-01), Kimura et al.
patent: 7737141 (2010-06-01), Kimura et al.
patent: 7880009 (2011-02-01), Kimura et al.
patent: 7923563 (2011-04-01), Kushida et al.
patent: 2001/0051642 (2001-12-01), Ahn et al.
patent: 2002/0128263 (2002-09-01), Mutel et al.
patent: 2003/0195201 (2003-10-01), Bo et al.
patent: 2003/0208082 (2003-11-01), Mutel et al.
patent: 2003/0225070 (2003-12-01), Mutel et al.
patent: 2004/0034096 (2004-02-01), Jolidon et al.
patent: 2004/0038969 (2004-02-01), Doherty et al.
patent: 2004/0063770 (2004-04-01), Ahn et al.
patent: 2004/0087798 (2004-05-01), Yamada
patent: 2004/0127494 (2004-07-01), Parker et al.
patent: 2004/0127555 (2004-07-01), Snow et al.
patent: 2004/0152743 (2004-08-01), Schoenafinger et al.
patent: 2004/0192743 (2004-09-01), Mjalli et al.
patent: 2004/0235864 (2004-11-01), Graczyk et al.
patent: 2005/0070538 (2005-03-01), Cheng et al.
patent: 2005/0131043 (2005-06-01), Mutel et al.
patent: 2005/0187277 (2005-08-01), Mjalli et al.
patent: 2006/0004013 (2006-01-01), Kimura et al.
patent: 2007/0117798 (2007-05-01), Kimura et al.
patent: 2007/0117839 (2007-05-01), Kimura et al.
patent: 2007/0219181 (2007-09-01), Kimura et al.
patent: 2007/0249833 (2007-10-01), Cheng et al.
patent: 2008/0070902 (2008-03-01), Kimura et al.
patent: 2008/0085894 (2008-04-01), Parker et al.
patent: 2008/0096892 (2008-04-01), Cheng et al.
patent: 2008/0280948 (2008-11-01), Baumann et al.
patent: 2009/0048213 (2009-02-01), Kimura et al.
patent: 2009/0048448 (2009-02-01), Kushida et al.
patent: 2009/0203916 (2009-08-01), Kushida et al.
patent: 2009/0270623 (2009-10-01), Shimomura et al.
patent: 1668593 (2005-09-01), None
patent: 3541716 (1987-05-01), None
patent: 0219756 (1987-04-01), None
patent: 0 270 091 (1988-06-01), None
patent: 0 589 491 (1994-03-01), None
patent: 1 264 820 (2002-12-01), None
patent: 0 973 768 (2003-07-01), None
patent: 1 757 591 (2007-02-01), None
patent: 1 808-432 (2007-07-01), None
patent: 1 953 151 (2008-08-01), None
patent: 1 953 158 (2008-08-01), None
patent: 1 992 618 (2008-11-01), None
patent: P 2006 3920 (2006-05-01), None
patent: 60-174781 (1985-09-01), None
patent: 3-206042 (1991-09-01), None
patent: 7-2780 (1995-01-01), None
patent: 8283219 (1996-10-01), None
patent: 10-510512 (1998-10-01), None
patent: 11-228548 (1999-08-01), None
patent: 3176365 (2001-04-01), None
patent: 2001-508767 (2001-07-01), None
patent: 2001-527083 (2001-12-01), None
patent: 2003-206280 (2003-07-01), None
patent: 2004-520292 (2004-07-01), None
patent: 2004-531519 (2004-10-01), None
patent: 2005-518371 (2005-06-01), None
patent: 2005-526807 (2005-09-01), None
patent: 2005-531596 (2005-10-01), None
patent: 2005-533092 (2005-11-01), None
patent: 2006-502247 (2006-01-01), None
patent: 2006-518738 (2006-08-01), None
patent: 2007-504282 (2007-03-01), None
patent: 2007-523903 (2007-08-01), None
patent: 2001126135 (2003-07-01), None
patent: 145500 (2007-09-01), None
patent: 379224 (2000-01-01), None
patent: 200400824 (2004-01-01), None
patent: WO 87/02587 (1987-05-01), None
patent: WO-91/12237 (1991-08-01), None
patent: WO 95/21832 (1995-08-01), None
patent: WO-96/10559 (1996-04-01), None
patent: WO-97/43287 (1997-11-01), None
patent: WO-98/03166 (1998-01-01), None
patent: WO-98/24785 (1998-06-01), None
patent: WO-00/07993 (2000-02-01), None
patent: WO-00/50391 (2000-08-01), None
patent: WO-00/51981 (2000-09-01), None
patent: WO-01/68585 (2001-09-01), None
patent: WO-01/81312 (2001-11-01), None
patent: WO 03/022273 (2003-03-01), None
patent: WO 03/027081 (2003-04-01), None
patent: WO-03/053912 (2003-07-01), None
patent: WO 03/062206 (2003-07-01), None
patent: WO-03/082292 (2003-10-01), None
patent: WO-03/101927 (2003-12-01), None
patent: WO 2004/002478 (2004-01-01), None
patent: WO-2004/007429 (2004-01-01), None
patent: WO-2004/007455 (2004-01-01), None
patent: WO-2005/020921 (2005-03-01), None
patent: WO-2005/063754 (2005-07-01), None
patent: WO 2005/072731 (2005-08-01), None
patent: WO-2005/115990 (2005-12-01), None
patent: WO 2006/018662 (2006-02-01), None
patent: WO-2006/046575 (2006-05-01), None
patent: WO-2006/112550 (2006-10-01), None
patent: WO-2007/034282 (2007-03-01), None
patent: WO-2007/060810 (2007-05-01), None
patent: WO-2007/102580 (2007-09-01), None
patent: WO-2008/013213 (2008-01-01), None
patent: WO-2008/097538 (2008-08-01), None
patent: WO 2008/137102 (2008-11-01), None
patent: WO-2008/137139 (2008-11-01), None
patent: WO-2008/156580 (2008-12-01), None
patent: WO-2009/020580 (2009-02-01), None
Rafii et al., BioMed Center, 7:7, (2009), pp. 1-4.
Hardy et al., Science, vol. 297, (2002), pp. 353-356.
http://downsyndrome.about.com/od/medicalissuesinds/a/DSAlzheimers—ro.htm.
http://www.sciencedaily.com/releases/2010/01/100115182639.htm.
Yuesong Gong et al.; Proceeding National Academy of Science, vol. 100, No. 18, pp. 10417-10422, Sep. 2, 2003.
Christoph Hock et al.; Neuron, vol. 38, No. 4, pp. 547-554, May 22, 2003.
Joseph T. Jarrett et al.; Biochemistry; vol. 32, No. 18, pp. 4693-4697, May 11, 1993.
George G. Glenner et al.; Biochemical and Biophysical Research Communications; vol. 120, No. 3, pp. 885-890, May 16, 1984.
Colin L. Masters et al.; Proceeding National Academy of Science; vol. 82, No. 12, pp. 4245-4249, Jun. 1985.
Gunnar K. Gouras et al.; American Journal of Pathology, vol. 156, No. 1, pp. 15-20, Jan. 2000.
D. Scheuner et al.; Nature Medicine, vol. 2, No. 8, pp. 864-870, Aug. 1996.
Mark S. Forman et al.; The Journal of Biological Chemistry; vol. 272, No. 51, pp. 32247-32253, Dec. 19, 1997.
Mark S. Shearman et al.; Biochemistry; vol. 39, No. 30, pp. 8698-8704, 2000.
Huw D. Lewis et al.; Biochemistry, vol. 42, No. 24, pp. 7580-7586, 2003.
Thomas A. Lanz et al., The Journal of Pharmacology and Experimental Therapeutics; vol. 39, No. 1, pp. 49-55, 2004.
Gwendolyn T. Wong et al.; The Journal of Biological Chemistry, vol. 279, No. 13, pp. 12876-12882, Mar. 26, 2004.
John P. Blass; Journal of Neuroscience Research, vol. 66, No. 1, pp. 851-856, 2001.
Genevieve Evin et al.; NeuroReport; vol. 13, No. 5, pp. 719-723, Apr. 16, 2002.
Osamu Yasuhara et al.; Neuroscience Letters, vol. 171, Nos. 1 and 2, pp. 63-66, 1994.
Jan T. Teller et al.; Nature Medicine, vol. 2, No. 1, pp. 93-95, Jan. 1996.
Takahiko Tokuda et al.; Annals Neurology, vol. 41, No. 2, pp. 271-273, Feb. 1997.
Yorihide Hayashi et al.; Brain Research; vol. 789, No. 2, pp. 307-314, 1998.
Helene Barelli et al.; Molecular Medicine, vol. 3, No. 10, pp. 695-707, Oct. 1997.
Michael E. Calhoun et al.; Proceeding National Academy of Science, vol. 96, No. 24, pp. 14088-14093, Nov. 23,
Doi Eriko
Hagiwara Hiroaki
Ito Koichi
Kaneko Toshihiko
Kawano Koki
Birch & Stewart Kolasch & Birch, LLP
Eisai R&D Management Co., Ltd.
Rahmani Niloofar
Seaman D M
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