Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-12-20
1998-12-08
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 435255, 4353201, 536 231, C12P 2106, C12N 500, C12N 1500, C07H 1700
Patent
active
058467726
ABSTRACT:
Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
REFERENCES:
patent: 5606022 (1997-02-01), Rasmussen
Gene 123(1) 99-103 (1993) The use of degenerate, sensor gene-specific, oligodeoxyribonucleotide primers to amplify DNA fragments from Staphlococcus aureus K. W. Bayles.
Biochemistry 32(9): 11741-11753 Structural conservation in the Che Y superfamily K. Volz.
Journal of Bacteriology 170(11): 5093-5101 Deduced Polypeptides Encoded by the Bacillus subtilis sacU Locus Share Homology with Two-Component Sensor-Regulator Systems Frank Kunst et al.
Hodgson John Edward
Wallis Nicola Gail
Carlson Karen Cochrane
Gimmi Edward R.
Hecht Elizabeth J.
King William T.
SmithKline Beecham p.l.c.
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