Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-07-26
2011-07-26
Zeman, Robert A (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C424S246100
Reexamination Certificate
active
07985837
ABSTRACT:
The present invention relates to two-component lantibiotics isolated fromBacillussp. Methods for producing said lantibiotics are provided, wherein dehydration and cyclization of the peptides is carried out by two substrate-specific modifying enzymes. Given the antimicrobial activity of the instant lantibiotics, methods for preventing or treating bacterial infections are also provided.
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Nagao et al Journal of Bioscience and Bioengineering vol. 2 Issue pp. 139-149.
Bowie et al (Science, 1990, 247:1306-1310).
Xie et al., “Lactiin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity”, Science 2004 303:679-681.
NCBI Accession No: BAB04173 [gi:10173067] with Revision History, Aug. 3, 2000-May 19, 2007.
NCBI Accession No: BAB04172 [gi:10173066] with Revision History, Aug. 3, 2000-May 19, 2007.
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Cooper Lisa E.
McClerren Amanda L.
van der Donk Wilfred A.
Archie Nina
Licata & Tyrrell P.C.
The Board of Trustees of the University of Illinois
Zeman Robert A
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